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Department of Chemistry, Graduate School of Science, Kyoto University

Yohei HIZUKURI (Assistant Professor)

Field of Expertise:
Biochemistry, Biophysics
Research interests:
Intramembrane proteolysis
Recent Papers & Books:
  1. Akiyama, K., Hizukuri Y., and Akiyama, Y. Involvement of a conserved GFG motif region in substrate binding by RseP, an Escherichia coli S2P protease. Mol. Microbiol. in press (2017)
  2. Hizukuri, Y., Akiyama, K., and Akiyama, Y. Biochemical characterization of function and structure of RseP, an Escherichia coli S2P protease. Methods Enzymol. 584, 1-34. (2017)
  3. Akiyama, K., Mizuno, S., Hizukuri, Y., Mori, H., Nogi, T., and Akiyama, Y. Roles of the membrane-reentrant β-hairpin-like loop of RseP protease in selective substrate cleavage. eLife. 4, e08928. (2015)
  4. 檜作 洋平,秋山 芳展. 膜内部での蛋白質分解とストレス応答制御. 別冊「医学のあゆみ」 レドックスUPDATE ストレス制御の臨床医学・健康医学 (監修:平家 俊男,淀井 淳司) 医歯薬出版株式会社. 69-74. (2015)
  5. Hizukuri, Y., Oda, T., Tabata, S., Tamura-Kawakami, K., Oi, R., Sato, M., Takagi, J., Akiyama, Y., and Nogi, T. A structure-based model of substrate discrimination by a non-canonical PDZ tandem in the intramembrane-cleaving protease RseP. Structure 22, 326-336. (2014)
  6. Hizukuri, Y., Ito, K., and Akiyama, Y. RseP peptidase. In Handbook of Proteolytic Enzymes, 3rd ed. Rawlings, N.D. and Salvesen, G. (eds). Amsterdam: Elsevier Ltd, 1546-1550. (2013)
  7. Hizukuri, Y. and Akiyama, Y. PDZ domains of RseP are not essential for sequential cleavage of RseA or stress-induced σE activation in vivo. Mol. Microbiol. 86, 1232-1245. (2012)
  8. Saito, A., Hizukuri, Y., Matsuo, E.-i., Chiba, S., Mori, H., Nishimura, O., Ito, K., and Akiyama, Y. Post liberation cleavage of signal peptides is catalyzed by the S2P protease in bacteria. Proc. Natl. Acad. Sci, USA. 108, 13740-13745. (2011)
Contact information:
Institute for Frontier Life and Medical Sciences
Phone: 81(Japan)-75-751-3995
Fax: 81(Japan)-75-771-5699
E-mail: yhizukur + @virus.kyoto-u.ac.jp
Gene analysis laboratory (internal link)
Institute for Frontier Life and Medical Sciences, Laboratory of Biological Membrane System
Akiyama Research Group web site

This page was last modified on 07 March 2017.

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