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Department of Chemistry, Graduate School of Science, Kyoto University

Yoshinori AKIYAMA (Professor)

Field of Expertise:
Molecular Biology
Research Interests:
  1. Quality control of membrane proteins
  2. Cell surface stress responses
  3. Intramembrane proteolysis
Recent Papers:
  1. Narita, S.-i., Masui, C., Suzuki, T., Dohmae, N., and Akiyama, Y. Protease homolog BepA (YfgC) promotes assembly and degradation of β-barrel membrane proteins in Escherichia coli. Proc. Natl. Acad. Sci. USA in press (2013)
  2. Hizukuri, Y. and Akiyama, Y. PDZ domains of RseP are not essential for sequential cleavage of RseA or stress-induced σE activation in vivo. Mol. Microbiol. 86, 1232-1245. (2012)
  3. Saito, A., Hizukuri, Y., Matsuo, E.-i., Chiba, S., Mori, H., Nishimura, O., Ito, K., and Akiyama, Y. (2011) Post liberation cleavage of signal peptides is catalyzed by the S2P protease in bacteria. Proc. Natl. Acad. Sci, USA, 108, 13740–13745.
  4. Akiyama, Y. (2009) Quality control of cytoplasmic membrane proteins in Escherichia coli. J. Biochem. 46, 449-454.
  5. Inaba, K., Suzuki, M., Maegawa, K., Akiyama, S., Ito, K., and Akiyama, Y. (2008) A pair of circularly permutated PDZ domains control RseP, the S2P family intramembrane protease of E. coli. J. Biol. Chem. 283, 35042-35052
  6. Koide, K., Ito. K., and Akiyama, Y. Substrate recognition and binding by RseP, an Escherichia coli intramembrane protease. J. Biol. Chem. 283, 9562-9570 (2008)
  7. Maegawa, S., Koide, K., Ito, K., and Akiyama, Y. The intramembrane active site of GlpG, an Escherichia coli rhomboid protease, is accessible to water and hydrolyzes an extramembrane peptide-bond of substrates. Mol. Microbiol. 64, 435-447 (2007)
  8. Shimohata, N., Nagamori, S., Akiyama, Y., Kaback, H.R., and Ito, K. SecY alterations that impair membrane protein folding and generate a membrane stress. J. Cell Biol. 176, 307-317 (2007)
  9. Akiyama, Y., Kanehara, K., and Ito, K. RseP (YaeL), an E. coli RIP protease, cleaves transmembrane sequences. EMBO J. 23, 4434-4442 (2004)
  10. Kanehara, K., Ito, K., and Akiyama, Y. YaeL (EcfE) activates the σE pathway of stress response through a site-2 cleavage of anti-σE, RseA. Genes Dev. 16, 2147-2155 (2002)
Contact Information:
Institute for Virus Research
Phone: 81(Japan)-75-751-4040
Fax: 81(Japan)- 75-771-5699
E-mail: yakiyama + @virus.kyoto-u.ac.jp
Gene analysis laboratory (internal link)
Akiyama Research Group web site

This page was last modified on 05 April 2018.

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