go to English now in Japanese

秋山 芳展(教授)

  1. 膜タンパク質品質管理機構の研究
  2. 膜ストレス応答機構の研究
  3. 膜内タンパク質分解の機構と細胞機能の研究
  1. Narita, S.-i., Masui, C., Suzuki, T., Dohmae, N., and Akiyama, Y. Protease homolog BepA (YfgC) promotes assembly and degradation of β-barrel membrane proteins in Escherichia coli. Proc. Natl. Acad. Sci. USA in press (2013)
  2. Hizukuri, Y. and Akiyama, Y. PDZ domains of RseP are not essential for sequential cleavage of RseA or stress-induced σE activation in vivo. Mol. Microbiol. 86, 1232-1245. (2012)
  3. Saito, A., Hizukuri, Y., Matsuo, E.-i., Chiba, S., Mori, H., Nishimura, O., Ito, K., and Akiyama, Y. Post liberation cleavage of signal peptides is catalyzed by the S2P protease in bacteria. Proc. Natl. Acad. Sci, USA, 108, 13740–13745.(2011)
  4. Akiyama, Y. Quality control of cytoplasmic membrane proteins in Escherichia coli. J. Biochem. 46, 449-454 (2009)
  5. Inaba, K., Suzuki, M., Maegawa, K., Akiyama, S., Ito, K., and Akiyama, Y. A pair of circularly permutated PDZ domains control RseP, the S2P family intramembrane protease of E. coli. J. Biol. Chem. 283, 35042-35052 (2008)
  6. Maegawa, S., Koide, K., Ito, K., and Akiyama, Y. The intramembrane active site of GlpG, an Escherichia coli rhomboid protease, is accessible to water and hydrolyzes an extramembrane peptide-bond of substrates. Mol. Microbiol. 64, 435-447 (2007)
  7. Shimohata, N., Nagamori, S., Akiyama, Y., Kaback, H.R., and Ito, K. SecY alterations that impair membrane protein folding and generate a membrane stress. J. Cell Biol. 176, 307-317 (2007)
  8. Akiyama, Y., Kanehara, K., and Ito, K. RseP (YaeL), an E. coli RIP protease, cleaves transmembrane sequences. EMBO J. 23, 4434-4442 (2004)
  9. Kanehara, K., Ito, K., and Akiyama, Y. YaeL (EcfE) activates the σE pathway of stress response through a site-2 cleavage of anti-σE, RseA. Genes Dev. 16, 2147-2155 (2002)
1988年 大学大学院理学研究科博士課程中退
1988年 京都大学ウイルス研究所助手
1999年 京都大学ウイルス研究所助教授
2007年 京都大学ウイルス研究所教授
部屋番号 ウイルス研究所本館2階201号室
電話番号 075-751-4040
電子メール yakiyama + @virus.kyoto-u.ac.jp


© Kyoto University 2008