Hiroyuki MORI (Associate Professor)

Field of Expertise:

Biochemistry, Molecular biology

Research interests:

1. Protein translocation,
2. Biogenesis of membrane proteins

Recent Papers:

1. Tsukazaki, T.*,Mori, H.*, Echizen, Y., Ishitani, R., Fukai, S., Tanaka, T., Perederina, A., Vassylyev, D. G., Kohno, T., Matsurana, A. D., Ito, K. and Nureki O.(2011) Structure and function of a membrane component SecDF that enhances protein export. Nature 474, 235-238. *These authors contributed equally to this work.
2. Tsukazaki, T.*, Mori, H.*, Fukai, S., Ishitani, R., Mori, T., Dohmae, N., Perederina, A., Sugita, Y., Vassylyev, D. G., Ito, K. and Nureki O. (2008) Conformational transition of Sec machinery inferred from bacterial SecYE structures. Nature 455, 988-991. *These authors contributed equally to this work.
3. Vassylyev, D. G., Mori, H., Vassylyeva, M. N., Tsukazaki, T., Kimura Y., Tahirov, H. T. & Ito K. (2006) Crystal structure of the translocation ATPase SecA from Thermus thermophilus reveals, a parallel, head-to-head dimer. J. Mol. Biol. 364, 248-258.
4. Mori H. & Ito, K. (2006) The long alpha-helix of SecA is important for mechanoconversion of its ATPase engine. J. Biol.Chem. 281, 36249-36256.
5. Mori, H. & Ito, K. (2006) Different modes of SecY-SecA interactions revealed by site-directed in vivo photo-cross-linking. Proc. Natl. Acad. Sci. USA. 103, .16159-16164
6. Mori, H., Shimokawa, N., Satoh, Y. & Ito, K. (2004) Mutational analysis of transmembrane regions 3 and 4 of SecY, a central component of protein translocase. J. Bacteriol. 186, 3960-3969
7. Mori, H., Tsukazaki, T., Masui, R., Kuramitsu, S., Yokoyama, S., Johnson, A. E., Kimura, Y., Akiyama, Y. & Ito, K. (2003) Fluorescence resonance energy transfer analysis of protein translocase: SecYE from Thermus thermophilus HB8 forms a constitutive oligomer in membrane. J. Biol. Chem. 278, 14257-14264.
8. Mori, H. & Ito, K. (2003) Biochemical characterization of a mutationally altered protein translocase: Protein motive force stimulation of the initiation phase of translocation. J. Bacteriol. 185, 405-412
9. Mori, H., Akiyama, Y. & Ito, K. (2003) A SecE mutation that modulates SecY-SecE translocase assembly, identified as a specific suppressor of SecY defects. J. Bacteriol. 185, 948-956
10. Mori, H. and Ito, K. (2001) An essential amino acid residue in the protein translocation channel revealed by targeted random mutagenesis of SecY. Proc. Natl. Acad. Sci. USA 98, 5128-5133 (2001)

Contact information:

Institute for Virus Research
Phone: 81 (Japan)-75-751-3995
Fax: 81 (Japan)-75-771-5699
E-mail: hiromori + @virus.kyoto-u.ac.jp

Link:

Gene analysis laboratory (internal link)
Akiyama Research Group web site

This page was last modified on 10 July 2020.