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■京化■京都大学理学部化学科・京都大学大学院理学研究科学専攻
　

遠藤 政幸（特定准教授）

専門分野
生物有機化学、ケミカルバイオロジー、DNAナノテクノロジー
研究テーマ
  1. 生体分子の空間を利用した1分子イメージング・分析法の開発
  2. DNAナノ構造体を利用した分子デバイス・分子システムの開発
  3. DNA分子デバイスの細胞機能制御への応用
代表的な論文
  1. K. Abe, Y. Hirose, H. Eki, K. Takeda, T. Bando, M. Endo, H. Sugiyama, X-ray crystal structure of a cyclic-PIP–DNA complex in the reverse-binding orientation. J. Am. Chem. Soc. 142, 10544-10549 (2020).
  2. S. Jonchhe, S. Pandey, D. Karna, P. Pokhrel, Y. Cui, S. Mishra, H. Sugiyama, M. Endo, H. Mao, DNA duplex is Weakened in Nanoconfinement. J. Am. Chem. Soc. 142, 10042-10049 (2020).
  3. I. Mela, P. Vallejo-Ramirez, S. Makarchuk, G. Christie, D. Bailey, R. Henderson, H. Sugiyama, M. Endo, C. Kaminski, DNA nanostructures as a tool for targeted antimicrobial delivery. Angew. Chem. Int. Ed. 59, 12698-12702 (2020).
  4. X. Xing, S. Sato, K. Hidaka, H. Sugiyama, M. Endo, Direct Observation and Analysis of TET-mediated Oxidation Processes in a DNA Origami Nanochip. Nucleic Acids Res. 48, 4041-4051 (2020).
  5. G. Raghavan, K. Hidaka, H. Sugiyama, M. Endo, Direct observation and analysis of the dynamics of the photoresponsive transcription factor GAL4. Angew. Chem. Int. Ed. 58, 7626-7630 (2019).
  6. D. Ishikawa, Y. Suzuki, C. Kurokawa, M. Ohara, M. Tsuchiya, M. Morita, M. Yanagisawa, M. Endo, R. Kawano, M. Takinoue, DNA origami nanoplate-based emulsion with designed nanopore function. Angew. Chem. Int. Ed. 58, 15299-15303 (2019).
  7. S. Jonchhe, S. Pandey, T. Emura, K. Hidaka, M. A Hossain, P Shrestha, H. Sugiyama, M. Endo, H. Mao, Decreased water activity in nanoconfinement contributes to the folding of G-quadruplex and i-motif structures. Proc. Natl. Acad. Sci. USA, 115, 9539-9544 (2018).
  8. T. Masubuchi, M. Endo, R. Iizuka, A. Iguchi, D. H. Yoon, T. Sekiguchi, H. Qi, R. Iinuma, Y. Miyazono, S. Shoji, T. Funatsu, H. Sugiyama, Y. Harada, T. Ueda, H. Tadakuma, Construction of integrated gene logic-chip. Nature Nanotechnology, 13, 933-940 (2018).
  9. Y. Suzuki, H. Sugiyama, M. Endo, Complexing DNA origami frameworks through sequential self-assembly based on shape-complementarity docking. Angew. Chem. Int. Ed. 57, 7061-7065 (2018).
  10. T. Kurokawa, S. Kiyonaka, E. Nakata, M. Endo, S. Koyama, E. Mori, N. H. Tran, H. Dinh, Y. Suzuki, K. Hidaka, M. Kawata, C. Sato, H. Sugiyama, T. Morii, Y. Mori, DNA Origami Scaffolds as Templates for Functional Tetrameric Kir3 K+ Channels. Angew. Chem. Int. Ed. 57, 2586-2591 (2018).
  11. A. Lee, M. Endo, J. Hobbs, C. Wälti, Direct Single-Molecule Observation of Mode and Geometry of RecA-Mediated Homology Search. ACS Nano, 12, 272-278 (2018).
  12. E. M. Willner, Y. Kamada, Y. Suzuki, T. Emura, K. Hidaka, H. Dietz, H. Sugiyama, M. Endo, Single-Molecule Observation of The Photoregulated Conformational Dynamics of DNA Origami Nanoscissors. Angew. Chem. Int. Ed. 56, 15324-15328 (2017).
  13. Y. Kobayashi, O. Misumi, M. Odahara, K. Ishibashi, M. Hirono, K. Hidaka, M. Endo, H. Sugiyama, H. Iwasaki, T. Kuroiwa, T. Shikanai, Y. Nishimura, Holliday-junction resolvases mediate chloroplast nucleoid segregation. Science, 356, 631-634 (2017).
  14. P. Shrestha, S. Jonchhe, T. Emura, K. Hidaka, M. Endo, H. Sugiyama, H. Mao, Confined Space Facilitates G-quadruplex Formation. Nature Nanotechnology, 12, 582−588 (2017).
  15. T. Shibata, Y. Fujita, H. Ohno, Y. Suzuki, K. Hayashi, K. R. Komatsu, S. Kawasaki, K. Hidaka, S. Yonehara, H. Sugiyama, M. Endo, H. Saito, Protein-driven RNA nanostructured devices that function in vitro and control mammalian cell fate. Nature Communications, 8, 540 (2017).
  16. M. H. Räz, K. Hidaka, S. J. Sturla, H. Sugiyama, M. Endo, Torsional Constraints of DNA Substrates Impact Cas9 Cleavage. J. Am. Chem. Soc. 138, 13842-13845 (2016).
  17. A. Kuzyk, Y. Yang, X. Duan, S. Stoll, A. O. Govorov, H. Sugiyama, M. Endo, N. Liu, A light-driven 3D plasmonic nanosystem that translates molecular motion into reversible chiroptical function. Nature Communications, 7, 10591 (2016).
  18. Y. Yang, M. Goetzfried, K. Hidaka, M. You, W. Tan, H. Sugiyama, M. Endo, Direct visualization of walking motions of a photo-controlled DNA nanomachine on the DNA nanostructure. Nano Lett. 15, 6672-6676 (2015).
  19. Y. Suzuki, M. Endo, H. Sugiyama, Lipid bilayer-supported two-dimensional self-assembly of DNA origami nanostructures. Nature Communications, 6, 8052 (2015).
  20. M. Endo, Y. Suzuki, T. Emura, K. Hidaka, F. Wang, I. Willner, H. Sugiyama, Single-Molecule Visualization of the Activity of Zn2+-Dependent DNAzyme. Angew. Chem. Int. Ed. 54, 10550-10554 (2015).
  21. M. Endo, X. Xing, X. Zhou, T. Emura, K. Hidaka, B. Tuesuwan, H. Sugiyama, Single-Molecule Manipulation of the Duplex Formation and Dissociation at the G-Quadruplex/i-Motif Site in the DNA Nanostructure. ACS Nano, 9, 9922-9929 (2015).
  22. M. Endo, H. Sugiyama, Single-Molecule Imaging of Dynamic Motions of Biomolecules in DNA Origami Nanostructures Using High-Speed Atomic Force Microscopy. Acc. Chem. Res. 47, 1645-1653 (2014).
  23. A. Rajendran, M. Endo, H. Sugiyama, State-of-the-Art High-Speed Atomic Force Microscopy for the Investigation of Single-Molecular Dynamics of Proteins. Chem. Rev. 114, 1493-1520 (2014).
  24. Y. Suzuki, M. Endo, Y. Katsuda, K. Ou, K. Hidaka, H. Sugiyama, DNA origami based visualization system for studying site-specific recombination events. J. Am. Chem. Soc. 136, 211-218 (2014).
  25. Y. Suzuki, M. Endo, Y. Yang, H. Sugiyama, Dynamic Assembly/Disassembly Processes of Photoresponsive DNA Origami Nanostructures Directly Visualized on a Lipid Membrane Surface. J. Am. Chem. Soc. 136, 1714-1717 (2014).
  26. A. Rajendran, M. Endo, K. Hidaka, H. Sugiyama, Direct and single-molecule visualization of the solution-state structure of G-hairpin and G-triplex intermediates. Angew. Chem. Int. Ed. 53, 4107−4112 (2014).
  27. M. Endo, S. Yamamoto, T. Emura, K. Hidaka, N. Morone, J. E. Heuser, H. Sugiyama, Helical DNA Origami Tubular Structures with Various Sizes and Arrangements. Angew. Chem. Int. Ed. 53, 7484-7490 (2014).
  28. D. Koirala, P. Shrestha, T. Emura, K. Hidaka, S. Mandal, M. Endo, H. Sugiyama, H. Mao, Single-Molecule Mechanochemical Sensing Using DNA Origami Nanostructures. Angew. Chem. Int. Ed. 53, 8137-8141 (2014).
  29. A. Rajendran, M. Endo, K. Hidaka, H. Sugiyama,Direct and real-time observation of rotary movement of a DNA nanomechanical device. J. Am. Chem. Soc. 135, 1117-1123 (2013).
  30. A. Rajendran, M. Endo, K. Hidaka, P. L. T. Tran, J.-L. Mergny, R. J. Gorelick, H. Sugiyama, HIV-1 Nucleocapsid Proteins as Molecular Chaperones for Tetramolecular Antiparallel G-Quadruplex Formation. J. Am. Chem. Soc. 135, 18575-18585 (2013).
  31. S. F. J. Wickham, J. Bath, Y. Katsuda, M. Endo, K. Hidaka, H. Sugiyama, A. J. Turberfield, A DNA-based molecular motor that can navigate a network of tracks. Nature Nanotechnology, 7, 169-173 (2012).
  32. M. Endo, R. Miyazaki, T. Emura, K. Hidaka, H. Sugiyama, Transcription Regulation System Mediated by Mechanical Operation of DNA Nanostructure. J. Am. Chem. Soc. 134, 2852-2855 (2012).
  33. T. Yoshidome, M. Endo, G. Kashiwazaki, K. Hidaka, T. Bando, H. Sugiyama, Sequence-Selective Single-Molecule Alkylation with a Pyrrole-Imidazole Polyamide Visualized in a DNA Nanoscaffold. J. Am. Chem. Soc. 134, 4654-4660 (2012).
  34. Y. Yang, M. Endo, K. Hidaka, H. Sugiyama, Photo-Controllable DNA Origami Nanostructures Assembling into Predesigned Multiorientational Patterns. J. Am. Chem. Soc. 134, 20645-20653 (2012).
  35. M. Endo, Y. Yang, Y. Suzuki, K. Hidaka, H. Sugiyama, Single-Molecule Visualization of the Hybridization and Dissociation of Photoresponsive Oligonucleotides and Their Reversible Switching Behavior in a DNA Nanostructure. Angew. Chem. Int. Ed. 51, 10518-10522 (2012).
  36. M. Endo, K. Tatsumi, K. Terushima, Y. Katsuda, K. Hidaka, Y. Harada, H. Sugiyama, Direct Visualization of the Movement of a Single T7 RNA Polymerase and Transcription on a DNA Nanostructure. Angew. Chem. Int. Ed. 51, 8778-8782 (2012).
  37. A. Rajendran, M. Endo, H. Sugiyama, Single-Molecule Analysis Using DNA Origami. Angew. Chem. Int. Ed. 51, 874-890 (2012).
  38. S. F. J. Wickham, M. Endo, Y. Katsuda, K. Hidaka, J. Bath, H. Sugiyama, A. J. Turberfield, Direct observation of stepwise movement of a synthetic molecular transporter. Nature Nanotechnology, 6, 166-169 (2011).
  39. A. Rajendran, M. Endo, K. Hidaka, H. Sugiyama, Photo-Cross-Linking-Assisted Thermal Stability of DNA Origami Structures and Its Application for Higher-Temperature Self-Assembly. J. Am. Chem. Soc. 133, 14488-14491 (2011).
  40. M. Endo, Y. Katsuda, K. Hidaka, H. Sugiyama, A versatile DNA nanochip for direct analysis of DNA base-excision repair. Angew. Chem. Int. Ed. 49, 9412−9416 (2010).
  41. M. Endo, Y. Katsuda, K. Hidaka, H. Sugiyama, Regulation of DNA Methylation Using Different Tensions of Double Strands Constructed in a Defined DNA Nanostructure. J. Am. Chem. Soc. 132, 1592−1597 (2010).
  42. Y. Sannohe, M. Endo, Y. Katsuda, K. Hidaka, H. Sugiyama, Visualization of Dynamic Conformational Switching of the G-Quadruplex in a DNA Nanostructure. J. Am. Chem. Soc. 132, 16311−16313 (2010).
  43. M. Endo, K. Hidaka, T. Kato, K. Namba, H. Sugiyama, DNA Prism Structures Constructed by Folding of Multiple Rectangular Arms. J. Am. Chem. Soc. 131, 15570–15571 (2009).
略歴
1992年　京都大学工学部合成化学科卒業
1997年　東京大学大学院工学系研究科 化学生命工学専攻 博士課程修了 　博士（工学）
1997年　東京医科歯科大学医用器材研究所 日本学術振興会特別研究員
1998年　ハーバード大学化学・ケミカルバイオロジー学科 Cancer Research Institute博士研究員
2000年　理化学研究所ゲノム科学センター 基礎科学特別研究員
2001年　大阪大学産業科学研究所 助手
2005年　大阪大学産業科学研究所 特任助教授・准教授
2008年　京都大学物質−細胞統合システム拠点 准教授
2018年　京都大学大学院理学研究科化学専攻 生体分子空間化学特別講座特定准教授　高等研究院物質−細胞統合システム拠点 連携准教授 (兼任)
連絡先
居室　物質―細胞統合システム拠点本館
電話番号　075-753-9765
電子メール　endo　＋　@kyoto-u.ac.jp
リンク
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（最終更新日；2020年08月05日）
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