Yoshida Minoru (Professor)

Field of Expertise:

Chemical Biology, Applied Microbiology, Cell Biology, Natural Product Chemistry

Research Interests:

1. Screening for novel bioactive compounds
2. Development of imaging probes to visualize drug action in living cells
3. Mode of action of Spliceostatin A, an anticancer agent
4. Functional analysis of protein acetylation

Recent Papers:

1. Ito, T., Umehara, T., Sasaki, K., Nakamura, Y., Nishino, N., Terada, T., Shirouzu, M., Padmanabhan, B., Yokoyama, S., Ito, A., and Yoshida, M. Real-time imaging of histone H4K12-specific acetylation determines the modes of action of histone deacetylase and bromodomain inhibitors. Chem. Biol., 18: 495-507 (2011)
2. Nishimura, S., Arita, Y., Honda, M., Iwamoto, K., Matsuyama, A., Shirai, A., Kawasaki, H., Kakeya, H., Kobayashi, T., Matsunaga, S., and Yoshida, M. Marine antifungal theonellamides target 3b-hydroxysterol to activate Rho1 signaling. Nature Chem. Biol., 6: 519-526 (2010)
3. Sasaki, K., Ito, T., Nishino, N., Khochbin, S., and Yoshida, M. Real-time imaging of histone H4 hyperacetylation in living cells. Proc. Natl. Acad. Sci. U.S.A., 106: 16257-16262 (2009)
4. Ho, C. H., Magtanong, L., Barker, S. L., Gresham, D., Nishimura, S., Natarajan, P., Koh, J. L. Y., Proter, J., Gray, C. A., Andersen, R. J., Giaever, G., Nislow, C., Andrews, B., Botstein, D., Graham, T. R., Yoshida, M., and Boone, C. A molecular barcoded yeast ORF library enables mode-of-action analysis of bioactive compounds. Nature Biotechnol., 27: 369-377 (2009)
5. Fukuda, I., Ito, A., Hirai, G., Nishimura, S., Kawasaki, H., Saitoh, H., Kimura, K.-i., Sodeoka, M., and Yoshida, M. Ginkgolic acid inhibits protein SUMOylation by blocking formation of the E1-SUMO intermediate. Chem. Biol., 16: 133-140 (2009)
6. Kaida, D., Motoyoshi, H., Tashiro, E., Nojima, T., Hagiwara, M., Ishigami, K., Watanabe, H., Kitahara, T., Yoshida, T., Nakajima, H., Tani, T., Horinouchi, S., and Yoshida, M. Spliceostatin A targets SF3b and inhibits both splicing and nuclear retention of pre-mRNA. Nature Chem. Biol., 3: 576-583 (2007)
7. Matsuyama, A., Arai, R., Yashiroda, Y., Shirai, A., Kamata, A., Sekido, S., Kobayashi, Y., Hashimoto, A., Hamamoto, M., Hiraoka, Y., Horinouchi, S., and Yoshida, M. ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe. Nature Biotechnol., 24: 841-847 (2006)
8. Matsuyama, A., Shimazu, T., Sumida, Y., Saito, A., Yoshimatsu, Y., Seigneurin-Berny, D., Osada, H., Komatsu, Y., Nishino, N., Khochbin, S., Horinouchi, S., and Yoshida, M. In vivo destabilization of dynamic microtubules by HDAC6-mediated deacetylation. EMBO J., 21: 6820-6831 (2002)
9. Hubbert, C., Guardiola, A., Shao, R., Kawaguchi, Y., Ito, A., Nixon, A., Yoshida, M., Wang, X.-F., and Yao, T.-P. HDAC6 is a microtubule-associated deacetylase. Nature, 417: 455-458 (2002)
10. Furumai, R., Komatsu, Y., Nishino, N., Khochbin, S., Yoshida, M., and Horinouchi, S. Potent histone deacetylase inhibitors built from trichostatin A and cyclic tetrapeptide antibiotics including trapoxin. Proc. Natl. Acad. Sci. U.S.A., 98: 87-92 (2001)

Education:

1981: B.Sc. University of Tokyo
1983: M.Sc. University of Tokyo
1986: Ph.D. University of Tokyo

Professional Appointments:

1986-1994 Assistant Professor, Department of Biotechnology, The University of Tokyo
1995-2002 Associate Professor, Department of Biotechnology, The University of Tokyo
2002- Chief Scientist, Chemical Genetics Lab, RIKEN
2002- Visiting Professor, Department of Biotechnology, University of Tokyo
2003- Visiting Professor, Graduate School of Science and Engineering, Saitama University
2008- Group Director, Chemical Genomics Research Group, and Chief Scientist, Chemical Genetics Lab, RIKEN Advanced Science Institute
2011- Visiting Professor, Graduate School of Science, Kyoto University

Awards:

1986 Japan Society for Bioscience, Biotechnology, and Agrochemistry Award for the Encouragement of Young Scientists
1998 Sumiki-Umezawa Memorial Award
2009 Japan Bioindustry Association Award
2010 Prizes for Science and Technology, The Commendation for Science and Technology by the Minister of Education, Culture, Sports, Science and Technology
2011 Japan Society for Bioscience, Biotechnology, and Agrochemistry Award

Contact Information:

Chemical Genetics Laboratory, RIKEN ASI
Hirosawa 2-1, Wako, Saitama 351-0198
Phone: 048-467-9516
Fax: 048-462-4676
Email: yoshidam + @riken.jp

Link:

Chemical Genomics Laboratory (internal link)
Chemical Genetics Laboratory (RIKEN)
Chemical Genomics Research Group (RIKEN)

This page was last modified on 05 April 2018.