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Department of Chemistry, Graduate School of Science, Kyoto University

Kunio MIKI (Professor)

Field of Expertise:
Structural Biology,
Protein Crystallography
Research Interests:
  1. Function of biological macromolecules elucidated by their three-dimensional structures
  2. Molecular mechanism of formation and maturation of three-dimensional structures of proteins
  3. Methodology in protein crystallography
Recent Papers:
  1. Structure of the LH1–RC Complex from Thermochromatium tepidum at 3.0 Å
    S. Niwa, L.-J. Yu, K. Takeda, Y. Hirano, T. Kawakami, Z.-Y. Wang-Otomo, and K. Miki
    Nature, 508, 228-232 (2014).
  2. Crystal Structures of the Carbamoylated and Cyanated Forms of HypE for [NiFe] Hydrogenase Maturation
    T. Tominaga, S. Watanabe, R. Matsumi, H. Atomi, T. Imanaka, and K. Miki
    Proc. Natl. Acad. Sci. USA, 110, 20485-20490 (2013).
  3. Substrate Distortion Contributes to the Catalysis of Orotidine 5'-monophosphate Decarboxylase
    M. Fujihashi, T. Ishida, S. Kuroda, L. P. Kotra, E. F. Pai, and K. Miki
    J. Am. Chem. Soc., 135, 17432-17443 (2013).
  4. Non-equivalence Observed for the 16-Meric Structure of a Small Heat Shock Protein, SpHsp16.0 from Schizosaccharomyces pombe
    Y. Hanazono, K. Takeda, T. Oka, T. Abe, T. Tomonari, N. Akiyama, Y. Aikawa, M. Yohda, and K. Miki
    Structure, 21, 220-228 (2013).
  5. Crystal Structures of the HypCD Complex and the HypCDE Ternary Complex: Transient Intermediate Complexes during [NiFe] Hydrogenase Maturation
    S. Watanabe, R. Matsumi, H. Atomi, T. Imanaka, and K. Miki
    Structure, 20, 2124-2137 (2012).
  6. Inter-subunit Interaction and Quaternary Rearrangement Defined by the Central Stalk of Prokaryotic V1-ATPase
    N. Numoto, Y. Hasegawa, K. Takeda, and K. Miki
    EMBO Rep., 10, 1228-1234 (2009).
  7. Crystal Structure of the Conserved N-terminal Domain of the Peroxisomal Matrix-Protein-Import Receptor, Pex14p
    J.-R. Su, K. Takeda, S. Tamura, Y. Fujiki, and K. Miki
    Proc. Natl. Acad. Sci. USA, 106, 417-421 (2009).
  8. Structural Basis of Oxidative Stress Sensing and DNA Distortion Mechanisms by a [2Fe-2S] Transcriptional Factor, SoxR
    S. Watanabe, A. Kita, K. Kobayashi, and K. Miki
    Proc. Natl. Acad. Sci. USA, 105, 4121-4126 (2008).
  9. Structural Basis for Regulation of Bifunctional Roles in Replication Initiator Protein
    A. Nakamura, C. Wada, and K. Miki
    Proc. Natl. Acad. Sci. USA, 104, 18484-18489 (2007).
  10. Structural Studies of the Cpx Pathway Activator NlpE on the Outer Membrane of Escherichia coli
    Y. Hirano, Md. M. Hossain, K. Takeda, H. Tokuda, and K. Miki
    Structure, 15, 963-976 (2007).
  11. Crystal Structures of [NiFe] Hydrogenase Maturation Proteins, HypC, HypD and HypE: Insights into Cyanation Reaction by Thiol Redox Signaling
    S. Watanabe, R. Matsumi, T. Arai, H. Atomi, T. Imanaka, and K. Miki
    Mol. Cell, 27, 29-40 (2007).
  12. Structure of an Extracellular Giant Haemoglobin of the Gutless Beard Worm Oligobrachia mashikoi
    N. Numoto, T. Nakagawa, A. Kita, Y. Sasayama, Y. Fukumori, and K. Miki
    Proc. Natl. Acad. Sci. USA, 102, 14521-14526 (2005).
  13. Crystal Structures of Bacterial Lipoprotein Localization Factors, LolA and LolB
    K. Takeda, H. Miyatake, N. Yokota, S. Matsuyama, H. Tokuda, and K. Miki
    EMBO J., 22, 3199-3209 (2003).
Contact Information:
Phone: 81(Japan)-75-753-4029,81(Japan)-75-753-4063 (secretary)
Fax: 81(Japan)-75-753-4032
E-mail: miki + @kuchem.kyoto-u.ac.jp
Link:
Biological Structural Chemistry Laboratory (internal link)
Miki Research Group web site

This page was last modified on 11 June 2014.

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