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Department of Chemistry, Graduate School of Science, Kyoto University
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Sugiyama Hiroshi (Professor)

Field of Expertise:
Chemical Biology, Bioorganic Chemistry
Research Interests:
  1. Chemistry of nucleic acid structure and function
  2. Development of tailor made antitumor agent
  3. Development of artificial genetic switch
  4. Development of DNA origami for single molecule analysis
Recent Papers:
  1. Transcriptional Inhibition of Progressive Renal Disease by the Gene Silencing Pyrrole-Imidazole polyamide Targeted to the TGF-β1Promoter. Matsuda, H.; Fukuda, N.; Ueno, T.; Katakawa, M.; Wang, X.; Watanabe, T.; Matsui, S.; Aoyama, T.; Saito, K.; Bando, T.; Matsumoto, Y.; Nagase, H.; Matsumoto, K.; Sugiyama, H. Kidney Int., 2011, 79, 46-56.
  2. Programmed Two-Dimensional Self-Assembly of Multiple DNA Origami Jigsaw Pieces. Rajendran, A.; Endo, M.; Katsuda, Y.; Hidaka, K.; Sugiyama, H. ACS Nano, 2011, 5, 665-671.
  3. Direct AFM Observation of an Opening Event of a DNA Cuboid Constructed via a Prism Structure. Endo, M.; Hidaka, K.; Sugiyama, H. Org. Biomol. Chem., 2011, 9, 2075-2077.
  4. Photo Controllable Sequence-Specific DNA Alkylation by Pyrrole-Imidazole Polyamide seco-CBI Conjugate. Park, S.; Bando, T.; Shinohara, K.; Sugiyama, H. Biocojug. Chem., 2011, 22, 120-124.
  5. Two-Dimensional DNA Origami Assemblies Using a Four-Way Connector. Endo, M.; Sugita, T.; Rajendran, A.; Katsuda, Y.; Emura, T.; Hidaka, K.; Sugiyama, H. Chem. Commun., 2011, 47, 3213-3215.
  6. Direct Observation of Stepwise Movement of a Synthetic Molecular Transporter. Wickham, S.F.J; Endo, M.; Katsuda, Y.; Hidaka, K.; Bath, J.; Sugiyama, H.; Turberfield, A. J. Nat. Nanotechnol., 2011, 6, 166-169.
  7. Recent Progress in DNA Origami Technology. Endo, M.; Sugiyama, H. Curr. Protoc. Nucleic Acid Chem., 2011, 12.8.1-17.8.19.
  8. Photo-Cross-Linking-Assisted Thermal Stability of DNA Origami Structures and Its Application for Higher-Temperature Self-Assembly. Rajendran, A.; Endo, M.; Katsuda, Y.; Hidaka, K.; Sugiyama, H. J. Am. Chem. Soc., 2011, 133, 14488-14491.
  9. Programmed Placement of Gold Nanoparticles Onto a Slit-Type DNA Origami Scaffold. Endo, M.; Yang, Y.; Emura, T.; Hidaka, K.; Sugiyama, H. Chem. Commun., 2011, 47, 10743-10745.
  10. Evalution of PI polyamide Conjugates With Eight-Base Pair Recognition and Improvement of The Aqueous Solubility by PEGylation. Takagaki, T.; Bando, T.; Kitano, M.; Hashiya, K.; Kashiwazaki, G.; Sugiyama, H. Bioorg. Med. Chem., 2011, 19, 5896-5902.
  11. Cysteine Cyclic Pyrrole-Imidazole Polyamide for Sequence-Specific Recognition In the DNA Minor Groove. Morinaga, H.; Bando, T.; Takagaki, T.; Yamamoto, M.; Hashiya, K.; Sugiyama, H. J. Am. Chem. Soc., 2011, 133, 18924-18930.
  12. A DNA Ligand Designed to Antagonize EBNA1 Represses EPSTEIN-BARR Virus-Induced Immortalization. Noguchi, K.; Yasuda, A.; Minoshima, M.; Kashiwazaki, G.; Kanda, T.; Katayama, K.; Mitsuhashi, J.; Bando, T.; Sugiyama, H.; Sugimoto, Y. Cancer Science, 2011, 102, 12, 2221-2230.
  13. Synthetic Small Molecules for Epigenetic Activation of Pluripotency Genes In Mouse Embryonic Fibroblasts. Pandian, G.N.; Shinohara, K.; Ohtsuki, A.; Nakano, Y.; Masafumi, M.; Bando, T.; Nagase, H.; Yamada, Y.; Watanabe, A.; Terada, N.; Sato, S.; Morinaga, H.; Sugiyama, H. ChemBioChem, 2011, 12, 2822-2828.
  14. Single-Molecule Platform for Investigation of Interaction Between G-Quadruplex and Small-Molecule Ligands. Koirala, D.; Dhakal, S.; Ashbridge, B.; Sannohe, Y.; Rodriguez, R.; Sugiyama, H.; Balasubramanian, S.; Mao, H. Nature Chemistry, 2011, 3, 782-787.
  15. Discrimination of T/A Versus A/T Base Pairs with Pyrrole-Imidazole Polyamides Substituted with a Chiralβ-Hyroxyl-γ-Aminobutyric acid/β-Alanine Pair. Zhang, W.; Jiang, S.K.; Wu, Y.L.; Guo, C.X.; Zhang, H.F.; Sugiyama, H.; Chen, X.L. ChemBioChem, 2012, 13, 47-50.
  16. Single-Molecule Analysis Using DNA Origami. Rajendran, A.; Endo, M.; Sugiyama, H. Angew. Chem. Int. Ed., 2012, 51, 874-890.
  17. Intramolecular Folding in Three Tandem Guanine Repeats of Human Telomeric DNA. Koirala, D.; Mashimo, T.; Sannohe, Y.; Yu, Z.; Mao, H.; Sugiyama, H. Chem.Commum., 2012, 48, 2006-2008.
  18. DNA Origami: Synthesis and Self-Assembly. Rajendran, A.; Endo, M.; Sugiyama, H. Curr. Protoc.Nucleic Acid Chem., In Press.
  19. Zinc Finger Proteins as Adaptor for Locating Proteins at Specific Addresses of DNA Origami. Nakata, E.; Fong, L.W.; Uwatoko, C.; Kiyonaka, S.; Mori, Y.; Katsuda, Y.; Endo, M.;Sugiyama, H.; Morii, T. Angew Chem. Int. Ed., In Press.
  20. A DNA-Based Molecular Motor that can Navigate a Network of Tracks. Wickham, S.F.J; Bath, J.; Katsuda, Y.; Endo, M.; Hidaka, K.; Sugiyama, H.; Tuberfield , A.J. Nat. Nanotechnol., In Press.
  21. Structural and Fuctional Analysis of Proteins by High-Speed Atomic Force Microscopy. Rajendran, A.; Endo, M.;Sugiyama, H. Adv. Protein Chem. Struct. Biol., In Press.
  22. SWI/SNF-Mediated Chromatin Remodeling Induces Z-DNA Formation on a Nucleosome. Mulholland, N.; Xu, Y.; Sugiyama, H.; Zhao, K. Cell and Bioscience, In Press.
  23. Single Strand DNA Catenane Synthesis Using the Formation of G-Quadruplex Structure. Sannohe, Y.; Sugiyama, H. Bioorganic and Medicinal Chemistry, In Press.
  24. Transcription Regulation System Mediated by Mechanical Operation of a DNA Nanostructure. Endo, M.; Miyazaki, R.; Emura, T.; Hidaka, k.;Sugiyama, H. J. Am. Chem. Soc., In Press.
  25. Synthesis and Biological Properties of Highly Sequence-Specific Alkylating N- Methylpyrrole- N- Methylimidazole (PI) Polyamide Conjugates. Kashiwazaki, G.; Bando, T.; Yoshidome, T.; Masui, S.; Takagaki, T.; Hashiya, K.;Pandian, G.N.; Yasuoka, J.; Akiyoshi, K.; Sugiyama, H. J. Med. Chem., In Press.
EDUCATIONAL BACKGROUND:
1979 B.S. Kyoto Univ. Department of Synthetic Chemistry.
1981 M.S. Kyoto Univ. Department of Synthetic Chemistry.
1984 Ph.D. Kyoto Univ. Department of Synthetic Chemistry.
1984 Research Associate at University of Virginia (USA).
1986 Research Associate at Kyoto University.
1987 Assistant Professor, Kyoto Univ. Department of Synthetic Chemistry.
1993 Associate Professor, Kyoto Univ. Department of Synthetic Chem. & Biological Chem.
1996 Professor, Tokyo Medical & Dental Univ. Institute of Biomaterials & Bioengineering.
2003 Professor, Kyoto Univ. Graduate School of Science, Department of Chemistry.
2008 Principal Investigator, Institute for Integrated Cell-Material Sciences (iCeMS).
IBM Japan Science Award (1999)
The CSJ Award for Creative Work (2005)
Editorial Advisory Board of ChemBioChem. (2005)
Editorial Advisory Board of J. Am. Chem. Soc. (2009)
Editional Board of J. Nucleic Acids. (2009)
Editorial Advisory Board of J. Med. Chem. (2011)
Editorial Board of The Chemical Record (2011)
Contact Information:
Phone: 81(Japan)-75-753-4047
Fax: 81(Japan)- 75-753-4050
E-mail: hs + @kuchem.kyoto-u.ac.jp
Link:
Chemical biology laboratory (internal link)
Sugiyama Research Group web site

This page was last modified on 09 February 2012.
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