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■京化■京都大学理学部化学科・京都大学大学院理学研究科学専攻
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杉山 弘（教授）

専門分野
ケミカルバイオロジー、生物有機化学
研究テーマ
  1. 核酸の構造と反応性に関する化学
  2. テーラーメイド抗がん剤の創製
  3. 遺伝子発現制御
  4. 単一分子観測のためのDNAオリガミのデザイン
代表的な論文
  1. Transcriptional Inhibition of Progressive Renal Disease by the Gene Silencing Pyrrole-Imidazole polyamide Targeted to the TGF-β1Promoter. Matsuda, H.; Fukuda, N.; Ueno, T.; Katakawa, M.; Wang, X.; Watanabe, T.; Matsui, S.; Aoyama, T.; Saito, K.; Bando, T.; Matsumoto, Y.; Nagase, H.; Matsumoto, K.; Sugiyama, H. Kidney Int., 2011, 79, 46-56.
  2. Programmed Two-Dimensional Self-Assembly of Multiple DNA Origami Jigsaw Pieces. Rajendran, A.; Endo, M.; Katsuda, Y.; Hidaka, K.; Sugiyama, H. ACS Nano, 2011, 5, 665-671.
  3. Direct AFM Observation of an Opening Event of a DNA Cuboid Constructed via a Prism Structure. Endo, M.; Hidaka, K.; Sugiyama, H. Org. Biomol. Chem., 2011, 9, 2075-2077.
  4. Photo Controllable Sequence-Specific DNA Alkylation by Pyrrole-Imidazole Polyamide seco-CBI Conjugate. Park, S.; Bando, T.; Shinohara, K.; Sugiyama, H. Biocojug. Chem., 2011, 22, 120-124.
  5. Two-Dimensional DNA Origami Assemblies Using a Four-Way Connector. Endo, M.; Sugita, T.; Rajendran, A.; Katsuda, Y.; Emura, T.; Hidaka, K.; Sugiyama, H. Chem. Commun., 2011, 47, 3213-3215.
  6. Direct Observation of Stepwise Movement of a Synthetic Molecular Transporter. Wickham, S.F.J; Endo, M.; Katsuda, Y.; Hidaka, K.; Bath, J.; Sugiyama, H.; Turberfield, A. J. Nat. Nanotechnol., 2011, 6, 166-169.
  7. Recent Progress in DNA Origami Technology. Endo, M.; Sugiyama, H. Curr. Protoc. Nucleic Acid Chem., 2011, 12.8.1-17.8.19.
  8. Photo-Cross-Linking-Assisted Thermal Stability of DNA Origami Structures and Its Application for Higher-Temperature Self-Assembly. Rajendran, A.; Endo, M.; Katsuda, Y.; Hidaka, K.; Sugiyama, H. J. Am. Chem. Soc., 2011, 133, 14488-14491.
  9. Programmed Placement of Gold Nanoparticles Onto a Slit-Type DNA Origami Scaffold. Endo, M.; Yang, Y.; Emura, T.; Hidaka, K.; Sugiyama, H. Chem. Commun., 2011, 47, 10743-10745.
  10. Evalution of PI polyamide Conjugates With Eight-Base Pair Recognition and Improvement of The Aqueous Solubility by PEGylation. Takagaki, T.; Bando, T.; Kitano, M.; Hashiya, K.; Kashiwazaki, G.; Sugiyama, H. Bioorg. Med. Chem., 2011, 19, 5896-5902.
  11. Cysteine Cyclic Pyrrole-Imidazole Polyamide for Sequence-Specific Recognition In the DNA Minor Groove. Morinaga, H.; Bando, T.; Takagaki, T.; Yamamoto, M.; Hashiya, K.; Sugiyama, H. J. Am. Chem. Soc., 2011, 133, 18924-18930.
  12. A DNA Ligand Designed to Antagonize EBNA1 Represses EPSTEIN-BARR Virus-Induced Immortalization. Noguchi, K.; Yasuda, A.; Minoshima, M.; Kashiwazaki, G.; Kanda, T.; Katayama, K.; Mitsuhashi, J.; Bando, T.; Sugiyama, H.; Sugimoto, Y. Cancer Science, 2011, 102, 12, 2221-2230.
  13. Synthetic Small Molecules for Epigenetic Activation of Pluripotency Genes In Mouse Embryonic Fibroblasts. Pandian, G.N.; Shinohara, K.; Ohtsuki, A.; Nakano, Y.; Masafumi, M.; Bando, T.; Nagase, H.; Yamada, Y.; Watanabe, A.; Terada, N.; Sato, S.; Morinaga, H.; Sugiyama, H. ChemBioChem, 2011, 12, 2822-2828.
  14. Single-Molecule Platform for Investigation of Interaction Between G-Quadruplex and Small-Molecule Ligands. Koirala, D.; Dhakal, S.; Ashbridge, B.; Sannohe, Y.; Rodriguez, R.; Sugiyama, H.; Balasubramanian, S.; Mao, H. Nature Chemistry, 2011, 3, 782-787.
  15. Discrimination of T/A Versus A/T Base Pairs with Pyrrole-Imidazole Polyamides Substituted with a Chiralβ-Hyroxyl-γ-Aminobutyric acid/β-Alanine Pair. Zhang, W.; Jiang, S.K.; Wu, Y.L.; Guo, C.X.; Zhang, H.F.; Sugiyama, H.; Chen, X.L. ChemBioChem, 2012, 13, 47-50.
  16. Single-Molecule Analysis Using DNA Origami. Rajendran, A.; Endo, M.; Sugiyama, H. Angew. Chem. Int. Ed., 2012, 51, 874-890.
  17. Intramolecular Folding in Three Tandem Guanine Repeats of Human Telomeric DNA. Koirala, D.; Mashimo, T.; Sannohe, Y.; Yu, Z.; Mao, H.; Sugiyama, H. Chem.Commum., 2012, 48, 2006-2008.
  18. DNA Origami: Synthesis and Self-Assembly. Rajendran, A.; Endo, M.; Sugiyama, H. Curr. Protoc.Nucleic Acid Chem., In Press.
  19. Zinc Finger Proteins as Adaptor for Locating Proteins at Specific Addresses of DNA Origami. Nakata, E.; Fong, L.W.; Uwatoko, C.; Kiyonaka, S.; Mori, Y.; Katsuda, Y.; Endo, M.;Sugiyama, H.; Morii, T. Angew Chem. Int. Ed., In Press.
  20. A DNA-Based Molecular Motor that can Navigate a Network of Tracks. Wickham, S.F.J; Bath, J.; Katsuda, Y.; Endo, M.; Hidaka, K.; Sugiyama, H.; Tuberfield , A.J. Nat. Nanotechnol., In Press.
  21. Structural and Fuctional Analysis of Proteins by High-Speed Atomic Force Microscopy. Rajendran, A.; Endo, M.;Sugiyama, H. Adv. Protein Chem. Struct. Biol., In Press.
  22. SWI/SNF-Mediated Chromatin Remodeling Induces Z-DNA Formation on a Nucleosome. Mulholland, N.; Xu, Y.; Sugiyama, H.; Zhao, K. Cell and Bioscience, In Press.
  23. Single Strand DNA Catenane Synthesis Using the Formation of G-Quadruplex Structure. Sannohe, Y.; Sugiyama, H. Bioorganic and Medicinal Chemistry, In Press.
  24. Transcription Regulation System Mediated by Mechanical Operation of a DNA Nanostructure. Endo, M.; Miyazaki, R.; Emura, T.; Hidaka, k.;Sugiyama, H. J. Am. Chem. Soc., In Press.
  25. Synthesis and Biological Properties of Highly Sequence-Specific Alkylating N- Methylpyrrole- N- Methylimidazole (PI) Polyamide Conjugates. Kashiwazaki, G.; Bando, T.; Yoshidome, T.; Masui, S.; Takagaki, T.; Hashiya, K.;Pandian, G.N.; Yasuoka, J.; Akiyoshi, K.; Sugiyama, H. J. Med. Chem., In Press.
略歴・受賞・役員
1982〜1984　京都大学大学院工学研究科博士課程
1984〜1986　ヴァージニア大学化学科博士研究員
1986～1987　日本学術振興会特別研究員
1988～1993　京都大学工学部合成化学科助手
1993～1996　京都大学工学部合成化学科助教授
1996～2003　東京医科歯科大学　生体材料工学研究所教授　
2003～　　　京都大学大学院理学研究科教授
2008〜　　　京都大学　物質細胞統合システム拠点(iCeMS)主任研究員
1999　日本IBM科学賞
2004　日本化学会学術賞
Editorial Advisory Board of ChemBioChem (2005〜).
Editorial Advisory Board of J. Am. Chem. Soc. (2009〜).
Editorial Board of J. Nucleic Acids (2009〜).
Editorial Advisory Board of J. Med. Chem. (2011).
Editorial Board of The Chemical Record (2011)
連絡先
電子メール　hs　＋　@kuchem.kyoto-u.ac.jp
リンク
生物化学分科紹介（京化サイト内）
生物化学研究室ホームページ

（最終更新日；2012年02月09日）
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