Toshikazu Bando (Associate Professor)

Field of Expertise:

Chemical Biology,

Organic Chemistry

Research Interests:

1. Design, Synthesis and Evaluation of Biological-functional molecules, pyrrole-imidazole polyamides conjugates.

Recent Papers:

1. Yoshidome, T.; Endo, M.; Kashiwazaki, G.; Hidaka, K.; Bando, T.; Sugiyama, H. Sequence-Selective Single Molecule Alkylation with a Pyrrole-Imidazole Polyamide Visualized in a DNA Nanoscaffold. J. Am. Chem. Soc., 2012, 134, 4654-4660.
2. Kashiwazaki, G.; Bando, T.; Yoshidome, T.; Masui, S.; Takagaki, T.; Hashiya, K.; Pandian, G.N.; Yasuoka, J.; Akiyoshi, K.; Sugiyama, H. Synthesis and Biological Properties of Highly Sequence-Specific Alkylating N- Methylpyrrole- N- Methylimidazole (PI) Polyamide Conjugates. J. Med. Chem. 2012, 55, 2057-2066.
3. Takagaki, T; Bando, T.; Sugiyama, H. Synthesis of Pyrrole-Imidazole Polyamide Seco-CBI Conjugates with a Vinyl Linker recognizing 7 bp DNA sequence. J. Am. Chem. Soc., 2012, 134, 13074-13081.
4. Park, S.; Bando, T.; Shinohara, K.; Sugiyama, H. Photo Controllable Sequence-Specific DNA Alkylation by Pyrrole-Imidazole Polyamide seco-CBI Conjugate. Biocojugate Chem. , 2011, 22, 120-124.
5. Morinaga, H.; Bando, T.; Takagaki, T.; Yamamoto, M.; Hashiya, K.; Sugiyama, H. Cysteine Cyclic Pyrrole-Imidazole Polyamide for Sequence-Specific Recognition In the DNA Minor Groove. J. Am. Chem. Soc., 2011, 133, 18924-18930.
6. Takagaki, T.; Bando, T.; Kitano, M.; Hashiya, K.; Kashiwazaki, G.; Sugiyama, H. Evalution of PI polyamide Conjugates With Eight-Base Pair Recognition and Improvement of The Aqueous Solubility by PEGylation. Bioorg. Med. Chem., 2011, 19, 5896-5902.

Contact Information:

Phone: 81(Japan)-75-753-4001
Fax: 81(Japan)-75-753-3670
E-mail: bando + @kuchem.kyoto-u.ac.jp

Link:

Chemical Biology Laboratory (internal link)
Sugiyama Laboratory

This page was last modified on 05 April 2018.